It means when someone is talking about something completely irrelevant to the topic being discussed, or that their response is not helpful.
It is uncertain where the expression originated, but it is likely to have come from target practice, where a shot that misses the bullseye is said to be “off the point.”
The teacher asked a question about the history of the United States, but the student’s answer was off the point, talking about the history of Canada.
The boss asked his employee to prepare a report on sales figures, but the employee’s report was off the point, talking about marketing strategies.
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